Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia

    May 2009 in “ International Journal of Dermatology ”
    May H. El‐Samahy, Maha Adel Shaheen, Dina E. B. Saddik, Nermeen S.A. Abdel Fattah, Mohammad A. El‐Sawi, Manal Z. Mahran, Abeer A. Shehab
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    TLDR AR gene not major factor in female hair loss; different from male hair loss.
    This study evaluated the androgen receptor (AR) gene as a candidate gene for female androgenetic alopecia (AGA) and found no significant difference in genotype or allele frequency between patients and controls. The study concluded that the AR gene is not a major contributing factor in the pathogenesis of female AGA and that female AGA should be considered a different disease from male AGA. The study suggests that other candidate genes affecting plasma and/or tissue androgen concentrations are required for phenotypic expression, and future genetic studies should be conducted on a larger scale with different types of female AGA.
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