Genetic Analysis of 5 Alpha Reductase Type 2 Enzyme in Relation to Oxidative Stress in Cases of Androgenetic Alopecia in a Sample of Egyptian Population

This study analyzed the genetic polymorphism of the 5α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia (AGA) in a sample of the Egyptian population. The study found a possible association between AGA and the V89L genetic polymorphism of 5-alpha reductase type II enzyme, with patients carrying the mutant leucine (L) allele having a higher risk for developing AGA. Additionally, there was a possible association between AGA and oxidative stress, with a significant increase in the level of superoxide dismutase and catalase in patients compared to the control group. The study provides insight into the genetic factors and oxidative stress involved in AGA in the Egyptian population.