Genetic Analysis of 5 Alpha Reductase Type 2 Enzyme in Relation to Oxidative Stress in Cases of Androgenetic Alopecia in a Sample of Egyptian Population

    October 2013 in “ Our Dermatology Online ”
    Ossama Hussein Roshdy, Nagat Sobhy Mohammad, Eman Soliman Kamha, Marwa Omar
    Studysummary This study found that individuals in this Egyptian cohort carrying the leucine (L) allele of the 5-α reductase type II enzyme had a higher risk of developing androgenetic alopecia, which may be associated with oxidative stress.
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    Research cited in this study 15

    1. Prevalence of Androgenic Alopecia in Women Aged 20-70 in Isfahan During 2008-2009 Journal of Pakistan Association of Dermatology · 2016
    2. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    3. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    4. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    5. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    6. Family History and Risk of Hair Loss Dermatology · 2004
    7. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    8. Androgenetic Alopecia in Women Journal of Investigative Dermatology Symposium Proceedings · 2003
    9. Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia Journal of Dermatological Science · 2003
    10. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    11. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    12. Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia Cell biochemistry and function · 2000
    13. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    14. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    15. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997