Genetic Analysis of 5 Alpha Reductase Type 2 Enzyme in Relation to Oxidative Stress in Cases of Androgenetic Alopecia in a Sample of Egyptian Population

October 2013 in “ Our Dermatology Online ”

Ossama Hussein Roshdy, Nagat Sobhy Mohammad, Eman Soliman Kamha, Marwa Omar

5α reductase type 2 androgenetic alopecia V89L genetic polymorphism 5-alpha reductase type II enzyme oxidative stress superoxide dismutase catalase 5-alpha reductase AGA SOD

Studysummary This study found that individuals in this Egyptian cohort carrying the leucine (L) allele of the 5-α reductase type II enzyme had a higher risk of developing androgenetic alopecia, which may be associated with oxidative stress.

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This study analyzed the genetic polymorphism of the 5α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia (AGA) in a sample of the Egyptian population. The study found a possible association between AGA and the V89L genetic polymorphism of 5-alpha reductase type II enzyme, with patients carrying the mutant leucine (L) allele having a higher risk for developing AGA. Additionally, there was a possible association between AGA and oxidative stress, with a significant increase in the level of superoxide dismutase and catalase in patients compared to the control group. The study provides insight into the genetic factors and oxidative stress involved in AGA in the Egyptian population.

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