Novel Shampoo Reduces Hair Shedding by Contracting the Arrector Pili Muscle via the Trace Amine-Associated Receptor

    July 2019 in “ Journal of Cosmetic Dermatology ”
    Maja Kovacevic, John McCoy, Andy Goren, Mirna Šitum, Andrija Stanimirović, Wei Liu, Yimei Tan, Sergio Vañó‐Galván, Jerry Shapiro, Rodney Sinclair
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    TLDR New shampoo with tyramine hydrochloride reduces hair loss by making a small muscle in the hair follicle contract.
    The study, involving 24 female participants, found that a shampoo containing tyramine hydrochloride, a trace amine-associated receptor (TAAR) agonist, reduced hair shedding by an average of 31%, with reductions up to 77%. The shampoo is believed to work by contracting the arrector pili muscle, which is linked to hair follicles. This suggests the presence of TAAR receptors in the arrector pili muscle and indicates the shampoo's potential as a treatment for hair shedding due to mechanical stress.
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