Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice

July 2015 in “ International journal of pharmacology ”

Sang-Oh Park, Byung-Sung Park, Ga-Yeong Noh

Natural Plant Extracts minoxidil VEGF KGF TGF-β1 anagen hair growth NPE Rogaine

TLDR Natural plant extracts help prevent hair loss and promote hair growth.

The study evaluated the effects of Natural Plant Extracts (NPE) on hair loss prevention and hair growth promotion in 30 male C57BL/6 mice, divided into three groups: control (saline), NPE, and minoxidil 5%. The NPE group showed significant improvements in hair density, length, and thickness, with the first hair growth observed on day 9. NPE significantly stimulated anagen hair growth and up-regulated VEGF and KGF mRNA expression while down-regulating TGF-β1 mRNA expression, suggesting that NPE promotes hair growth and prevents hair loss through genetic regulation.

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