Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health

January 2017 in “ Evidence-based Complementary and Alternative Medicine ”

Jae-Ho Yu, Biki Gupta, Hyoung Geun Park, Miwon Son, Joon-Ho Jun, Chul Soon Yong, Jeong Ah Kim, Jong Oh Kim

DA-5512 herbal extract human dermal papilla cells hair follicles minoxidil alopecia hair density hair-shaft diameter hair-growth rate Rogaine

Studysummary This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%). Our plain-language summary of this paper — not a Tressless recommendation.

The 2017 study evaluated the proprietary herbal extract DA-5512 for its potential to stimulate hair growth and improve hair health. In vitro tests showed that DA-5512 increased the viability and proliferation of human dermal papilla cells. In vivo experiments on mice demonstrated that DA-5512 at 1% and 5% concentrations promoted hair growth and increased the number and length of hair follicles, with effects comparable to 3% minoxidil. A clinical trial involving 23 participants with mild alopecia compared 5% DA-5512, 3% minoxidil, and a placebo over 16 weeks. The results indicated that 5% DA-5512 significantly improved hair density, hair-shaft diameter, and hair-growth rate, outperforming 3% minoxidil, with no reported adverse effects. The study concluded that DA-5512 is an effective treatment for hair loss, although the mechanisms of action require further investigation.

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