5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond

    Bodie Chislett, David Chen, Marlon Perera, Eric Chung, Damien Bolton, Liang G. Qu
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    TLDR 5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.
    The document discusses the use and potential applications of 5-alpha reductase inhibitors (5-ARIs), such as finasteride and dutasteride. Initially used for benign prostatic hyperplasia, their use has expanded to include androgenetic alopecia and hirsutism. The drugs work by inhibiting the enzyme that converts testosterone to dihydrotestosterone. There are new associations between 5-ARIs and reduced severity and mortality of SARS-CoV-2, but more research is needed to confirm these findings. Adverse effects of 5-ARIs can include sexual dysfunction and depressive symptoms. The document also discusses the potential use of 5-ARIs in prostate cancer prevention, but the lack of clinical indication should be re-examined.
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