Examining the Effect of Notocactus Ottonis Cold Vacuum Isolated Plant Cell Extract on Hair Growth in C57BL/6 Mice

February 2023 in “ Molecules ”

Junko Shibato, Fumiko Takenoya, Ai Kimura, Cheol Woo Min, Michio Yamashita, Ravi Gupta, Sun Tae Kim, Randeep Rakwal, Seiji Shioda

Notocactus ottonis N-CE minoxidil MXD hair follicles growth-promoting factors proteins genes hair growth Rogaine

TLDR Cactus extract from Notocactus ottonis may help promote hair growth.

The study investigated the effects of a cell extract from the cactus Notocactus ottonis (N-CE) on hair growth in male C57BL/6 mice. The extract was compared to a vehicle control (VC) and minoxidil (MXD), a known hair growth promoter. The results showed that N-CE and MXD were more effective in promoting hair growth than VC, with N-CE increasing the number of hair follicles. The study also found that N-CE contained growth-promoting factors and altered the expression of certain proteins and genes related to hair growth. The study involved 6 mice per group, with groups treated with 10% N-CE, 3% MXD, and a vehicle control group. The study suggests the potential of using N. ottonis CE as a hair-growth-promoting agent.

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