Inhibitory Effects of Polyacetylene Compounds from Panax Ginseng on Neurotrophin Receptor-Mediated Hair Growth
January 2017
in “
Biological & Pharmaceutical Bulletin
”
polyacetylene compounds Panax ginseng panaxynol panaxydol panaxydol chlorohydrin 1,8-heptadecadiene-4,6-diyne-3,10-diol panaxytriol dihydropanaxacol neurotrophic factors BDNF β-NGF TrkB p75NTR hydroxyl moieties hair growth disorders alopecia ginseng brain-derived neurotrophic factor nerve growth factor
TLDR Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.
The 2017 study demonstrated that polyacetylene compounds from Panax ginseng, specifically panaxynol, panaxydol, panaxydol chlorohydrin, 1,8-heptadecadiene-4,6-diyne-3,10-diol, panaxytriol, and dihydropanaxacol, can inhibit the binding of neurotrophic factors like BDNF and β-NGF to their respective receptors, TrkB and p75NTR. This inhibition was found to be dose-dependent and particularly significant for compounds 4, 5, and 6. The presence of hydroxyl moieties in these compounds was crucial for their inhibitory effect. These findings suggest that polyacetylene compounds with hydroxyl groups could be beneficial in treating hair growth disorders by blocking neurotrophin receptor interactions, offering a new potential treatment pathway for conditions such as alopecia.
