Harnessing miRNA Milk-Derived Exosomes for Hair Loss Disorders: In Vitro Modulation of WNT Signaling and Dermal Papilla Proliferation

    February 2026 in “ Cosmetics ”
    Daniela Pinto, Giorgia Mondadori, Monica Cozzi, Piero Tesauro, Martin Hintersteiner, Raúl López Domínguez, Esperanza De Santiago Rodriguez, Giammaria Giuliani, Fabio Rinaldi
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    TLDR Milk-derived exosomes may help treat hair loss by boosting hair follicle growth.
    This study explores the use of bovine milk-derived exosomes (MEV-miRNAs) for treating hair loss disorders such as androgenetic alopecia and telogen effluvium. The research found that MEV-miRNAs can enhance the viability of hair follicle dermal papilla cells by 24.27% after 24 hours and significantly up-regulate WNT pathway components, which are crucial for hair follicle growth. Although human hair follicles showed a non-significant trend towards increased elongation, the findings suggest that MEV-miRNAs could be a promising therapeutic strategy for hair loss by modulating key signaling pathways. Further in vivo studies are needed to confirm these effects.
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