New Technologies for Hair Follicle Growth and Regeneration: Comparison Between Different Commercial Products Containing Exosomes

November 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Greta Ferrugia, Massimo Zimbone, Maria Violetta Brundo

exosomes hair follicle growth hair regeneration stem cells umbilical cord lining bovine colostrum growth factors cytokines hair bulb growth dermal papilla regeneration stem cell exosomes bovine colostrum exosomes

TLDR Exosomes from bovine colostrum may be effective for hair growth and slowing hair loss.

The study investigates the effects of two commercial products containing exosomes on hair growth and regeneration in human hair follicle cultures. One product uses exosomes and proteins from stem cells derived from the umbilical cord lining, while the other contains exosomes from bovine colostrum, loaded with growth factors and cytokines. Results showed that the bovine colostrum-derived exosomes significantly enhanced hair bulb growth and dermal papilla regeneration compared to the stem cell-derived exosomes, which performed similarly to untreated controls. This suggests that exosomes from bovine colostrum could be effective in slowing hair loss and promoting new hair growth.

View this study on biorxiv.org →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Effectiveness of a Novel Compound Hair and Scalp Complex on Hair Follicle Regeneration

January 2024 in “Cosmetics”

HAIR & SCALP COMPLEX may help treat hair loss by stimulating hair growth and restarting the hair cycle.

research Exosomes for Hair Growth and Regeneration

November 2023 in “Journal of Bioscience and Bioengineering”

Exosomes show promise for hair growth but face challenges in standardization and concentration for clinical use.

research Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

104 citations , January 2023 in “Journal of Clinical Medicine”

A holistic approach is needed to effectively address hair loss by understanding and influencing the hair growth cycle.

research Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

12 citations , April 2022 in “Journal of cosmetic dermatology”

Exosome therapy could help with hair loss, but more research is needed to confirm its safety and effectiveness.

research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

5 citations , March 2022 in “Frontiers in Cell and Developmental Biology”

Colostrum-derived exosomes can promote hair growth and may be a promising treatment for hair loss.

research Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid

42 citations , June 2019 in “Aging”

3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research Hair Cosmetics: An Overview

193 citations , January 2015 in “International journal of trichology”

Dermatologists need to understand hair products to treat hair and scalp issues better.

research An Overview of Alopecias

53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research Hair Growth and Rejuvenation: An Overview

81 citations , June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata

91 citations , March 1996 in “Archives of Dermatological Research”

Certain cytokines and growth factors can inhibit hair growth and may affect alopecia areata.

Related Research

3 / 3 results

Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

research Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

August 2014 in “Journal of clinical & experimental dermatology research”

Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.

research Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model

17 citations , December 2010 in “Journal of Investigative Dermatology”

Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.

research Fullerene Nanomaterials Potentiate Hair Growth

36 citations , June 2009 in “Nanomedicine”

Fullerene nanomaterials help hair grow faster and increase hair follicles.