TLDR Let-7b helps alpaca hair grow by reducing TGFβR I protein.
The study concluded that TGFβR I is a target gene of let-7b, and let-7b can regulate TGFβR I expression through transcriptional repression, thereby promoting alpaca hair growth. This finding was supported by experiments involving three young male alpacas, where real-time PCR showed that TGFβR I abundance in ear skin was 7.988 times higher than in back skin. The research highlighted the role of the TGF-β/Smads signaling pathway in hair follicle regulation and was funded by grants from The National Natural Science Foundation of China and the Shanxi Agricultural University Research Startup Project.
92 citations,
June 2005 in “Journal of Investigative Dermatology” All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
190 citations,
October 2002 in “The FASEB journal” Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.
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October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
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October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
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December 2020 in “Frontiers in cell and developmental biology” miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
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December 2022 in “Frontiers in Bioengineering and Biotechnology” Extracellular vesicles show promise for wound healing, but more research is needed to improve their stability and production.
