TLDR Let-7b helps alpaca hair grow by reducing TGFβR I protein.
The study concluded that TGFβR I is a target gene of let-7b, and let-7b can regulate TGFβR I expression through transcriptional repression, thereby promoting alpaca hair growth. This finding was supported by experiments involving three young male alpacas, where real-time PCR showed that TGFβR I abundance in ear skin was 7.988 times higher than in back skin. The research highlighted the role of the TGF-β/Smads signaling pathway in hair follicle regulation and was funded by grants from The National Natural Science Foundation of China and the Shanxi Agricultural University Research Startup Project.
92 citations
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June 2005 in “Journal of Investigative Dermatology” All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
190 citations
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October 2002 in “The FASEB journal” Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.
12 citations
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October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
11 citations
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October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
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December 2020 in “Frontiers in cell and developmental biology” miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
24 citations
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August 2021 in “Biologics” Stem cell therapy shows promise in improving burn wound healing.
7 citations
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December 2022 in “Frontiers in Bioengineering and Biotechnology” Extracellular vesicles show promise for wound healing, but more research is needed to improve their stability and production.
