Let-7b Promotes Alpaca Hair Growth via Transcriptional Repression of TGFβR I

    November 2015 in “ Gene ”
    Siyu Yan, Yu Zhang, Ning Liu, Haidong Wang, Jun Xie, Shu‐Yuan Gao, Jia‐Qi Cheng, Xiuju Yu, Ting Wang, Changsheng Dong, Xiaopeng He
    TLDR Let-7b helps alpaca hair grow by reducing TGFβR I protein.
    The study concluded that TGFβR I is a target gene of let-7b, and let-7b can regulate TGFβR I expression through transcriptional repression, thereby promoting alpaca hair growth. This finding was supported by experiments involving three young male alpacas, where real-time PCR showed that TGFβR I abundance in ear skin was 7.988 times higher than in back skin. The research highlighted the role of the TGF-β/Smads signaling pathway in hair follicle regulation and was funded by grants from The National Natural Science Foundation of China and the Shanxi Agricultural University Research Startup Project.
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