The Fundamentals of WNT10A

January 2025 in “ Differentiation ”

Erica L Benard, Matthias Hammerschmidt

WNT10A ectodermal organogenesis tissue regeneration ectodermal dysplasia syndromes Odonto-oncho-dermal dysplasia Schöpf-Schulz-Passarge syndrome selective tooth agenesis fibrosis carcinogenesis

TLDR WNT10A is important for tissue development and linked to various human disorders.

WNT10A is a secreted glycoprotein crucial for ectodermal organogenesis and tissue regeneration, with its significance first noted in 2006 in relation to cleft lip and palate. This review details the WNT10A gene and protein structure, expression patterns across species, and its roles in tissue and organ development. It highlights the connection between WNT10A loss-of-function mutations and human disorders such as ectodermal dysplasia syndromes, Odonto-oncho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, and selective tooth agenesis. Additionally, it discusses the association of increased WNT10A activity with conditions like fibrosis and carcinogenesis.

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research Short Anagen Hair Syndrome: Association With Mono- and Biallelic Variants in WNT10A and a Genetic Overlap With Male Pattern Hair Loss

September 2023 in “British Journal of Dermatology”

Some cases of short anagen hair syndrome are linked to specific genetic variations that are also connected to male pattern baldness.

research Evidence for a Functional Interaction of WNT10A and EBF1 in Male-Pattern Baldness

12 citations , September 2021 in “PLoS ONE”

WNT10A and EBF1 interaction affects hair growth in male-pattern baldness.

research WNT10A, Dermatology and Dentistry

30 citations , June 2021 in “British Journal of Dermatology”

Mutations in the WNT10A gene can cause skin, hair, teeth, and other disorders, and may also affect other areas like kidney and cancer, with potential for targeted treatments.

research Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

49 citations , July 2019 in “British Journal of Dermatology”

Wnt signaling is important for the change from the resting phase to the growth phase in human hair cycles.

research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation

96 citations , June 2017 in “Nature Communications”

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations , April 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.