Evidence for a Functional Interaction of WNT10A and EBF1 in Male-Pattern Baldness

    September 2021 in “ PLoS ONE ”
    Lara M. Hochfeld, Marta Bertolini, David Broadley … Stefanie Heilmann‐Heimbach
    Studysummary In this study, researchers found that interaction between transcription factor EBF1 and gene WNT10A, influenced by a genetic variant, may play a role in hair shaft formation and anagen shortening in male pattern baldness.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.plos.org →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    2. Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods Journal of Dermatological Science · 2019
    3. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    4. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    5. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    6. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    7. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    8. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    9. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    10. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    11. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    12. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    13. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    14. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    15. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    16. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    17. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993