Androgenetic Alopecia in Men: An Update on Genetics

    Ilakkia Priya Sadasivam, Sambandam Ravikumar, Damayandhi Kaliyaperumal, Jude Ernest Dileep
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    TLDR Androgenetic alopecia in men is genetic and linked to health issues like obesity and heart disease, with treatments including minoxidil, finasteride, and hair transplants.
    The document provides an update on the genetics of androgenetic alopecia (AGA) in men, emphasizing the role of the androgen receptor (AR) gene and other genetic loci. It discusses the psychological impact of AGA and current FDA-approved treatments like finasteride and minoxidil, as well as hair transplants for advanced cases. Emerging therapies such as gene therapy, growth factors, stem cell, and exosome therapy are also highlighted. The document notes the association of AGA with increased risks of cardiovascular disease and insulin resistance, and underscores the need for reliable biomarkers for early detection and progression prediction. Advances in molecular techniques could lead to more effective treatments.
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