Pilot Study: Genetic Distribution of AR, FGF5, SULT1A1, and CYP3A5 Polymorphisms in Male Mexican Population with Androgenetic Alopecia

January 2022 in “ PubMed ”

Daniela Martinez-Chapoy, Francisco J Cruz-Arroyo, Francisco D Ancer-Leal, Regina A Rodriguez-Leal, Bianka D Camacho-Zamora, Daniela A Guzman-Sanchez, Nelly A Espinoza-Gonzalez, Lizeth Martinez-Jacobo, Ivan A Marino-Martinez

androgenetic alopecia AR FGF5 SULT1A1 CYP3A5 single nucleotide polymorphisms SNPs Real Time-PCR rs1042028 rs788068 rs1042157 AGA

Studysummary This study reported the genotypic and allelic frequencies of seven SNPs associated with androgenetic alopecia in Mexican individuals, highlighting significant differences in one SNP between cases and controls in Western Mexico. Our plain-language summary of this paper — not a Tressless recommendation.

This pilot study investigated the genetic distribution of specific single nucleotide polymorphisms (SNPs) associated with androgenetic alopecia (AGA) and drug metabolism in a male Mexican population. The study involved 125 participants (60 controls and 65 cases) from Northern and Western Mexico. Using Real Time-PCR, the researchers genotyped SNPs in genes AR, FGF5, SULT1A1, and CYP3A5. Notably, the SULT1A1 SNPs rs1042028 and rs788068 showed a 100% distribution of the ancestral allele C and mutated allele A, respectively, with rs1042028 diverging from previously reported frequencies. Some SNPs were not in Hardy-Weinberg equilibrium, while others were. A significant difference in the rs1042157 allelic frequency was found between cases and controls in Western Mexico. The study provides valuable data on the genotypic and allelic frequencies of these SNPs in the Mexican population.

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