Androgenetic Alopecia and Insulin Resistance in Young Men

October 2009 in “ Clinical Endocrinology ”

José Gerardo González-González, Leonardo Mancillas-Adame, Mercedes Fernández-Reyes, Minerva Gómez-Flores, Fernando J. Lavalle-González, Jorge Ocampo-Candiani, Jesús Zacarías Villarreal-Pérez

androgenetic alopecia insulin resistance metabolic syndrome Hamilton-Norwood classification AGA

TLDR Hair loss in young men linked to higher risk of insulin resistance and metabolic issues.

This study from 2009 investigated the relationship between androgenetic alopecia (AGA) and insulin resistance in young men. The study found that young male AGA cases had a higher prevalence of insulin resistance and metabolic syndrome than controls. The study recommends assessing insulin resistance and cardiovascular-related features and disorders in all young males with stage III or higher AGA, according to the Hamilton-Norwood classification. The study suggests that AGA may be a marker for insulin resistance and that young men with AGA should be screened for metabolic disorders.

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Research cited in this study

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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The user has been using a combination of oral finasteride, oral dutasteride, topical and oral minoxidil, microneedling, and keto shampoo for hair loss, experiencing significant shedding recently. Suggestions include simplifying the regimen by dropping finasteride and topical minoxidil, and possibly adding RU58841, while others advise maintaining the current approach for consistent results.

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