research Case Report of Schöpf–Schulz–Passarge Syndrome Resulting from a Missense Mutation, p.Arg104Cys, in WNT10A
A new gene mutation caused a man's rare skin condition, Schöpf-Schulz-Passarge syndrome.
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research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes
WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.
research The Fundamentals of WNT10A
WNT10A is a secreted glycoprotein crucial for ectodermal organogenesis and tissue regeneration, with its significance first noted in 2006 in relation to cleft lip and palate. This review details the WNT10A gene and protein structure, expression patterns across species, and its roles in tissue and organ development. It highlights the connection between WNT10A loss-of-function mutations and human disorders such as ectodermal dysplasia syndromes, Odonto-oncho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, and selective tooth agenesis. Additionally, it discusses the association of increased WNT10A activity with conditions like fibrosis and carcinogenesis.
research Inherited Disorders of the Hair
The document explains the genetic causes and characteristics of inherited hair disorders.
research Hair Disorders
Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
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