Short Anagen Hair Syndrome: Association With Mono- and Biallelic Variants in WNT10A and a Genetic Overlap With Male Pattern Hair Loss

September 2023 in “ British Journal of Dermatology ”

Nicole Cesarato, Agnes Schwieger‐Briel, Yasmina Gossmann, S. Henne, Kathrin Hillmann, Leonie Frommherz, Maria Wehner, Xing Xiong, Holger Thiele, Vinzenz Oji, Donatella Milani, Iliana Tantcheva‐Poór, Kathrin Giehl, Regina Fölster‐Holst, Anne Teichler, Delphine Braeckmans, Peter H. Hoeger, Gabriela Jones, Jorge Frank, Lisa Weibel, Ulrike Blume-Peytavi, Henning Hamm, Markus M. Nöthen, Matthias Geyer, Markus M. Nöthen, F. Buket Basmanav, Regina C. Betz

short anagen hair syndrome WNT10A male pattern hair loss androgenic alopecia MPHL

Studysummary This study found that WNT10A variants are associated with short anagen hair in children and may overlap genetically with male pattern hair loss.

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research Short Anagen Syndrome: A Case Series and Algorithm for Diagnosis

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research WNT10A, Dermatology and Dentistry

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This review discusses the association between WNT10A gene variants and various ectodermal disorders, highlighting their clinical relevance in dermatology and dentistry, but reports no new findings.

research Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

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This study found that Wnt signalling agonists increase and antagonists decrease in human scalp follicles from telogen to early-anagen, with differences from the mouse model suggesting targeted interventions for hair growth disorders.

research Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness

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This study found that male pattern baldness in European males is strongly heritable and associated with genetic markers linked to earlier puberty, bone density, and pancreatic function.

research Short Anagen Syndrome: Case Series and Literature Review

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This review describes the clinical characteristics and confirms the diagnosis of short anagen syndrome in the largest reported series to date, comparing it to loose anagen syndrome.

research GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

57 citations , November 2017 in “Nature Communications”

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research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation

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This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.

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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

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This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.

research Minoxidil Improved Hair Density in an Asian Girl with Short Anagen Syndrome: A Case Report and Review of Literature

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This case report describes an Asian girl with short anagen syndrome who experienced improved hair density after using minoxidil.

research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

46 citations , February 2016 in “Experimental Dermatology”

This review discusses the genetic research developments in androgenetic alopecia, reporting no new clinical results, and highlights the potential for discovering novel therapeutic targets.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

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research Short Anagen Syndrome in a Girl with Curly Dark Hair and Consanguineous Parents

5 citations , November 2012 in “Journal of the American Academy of Dermatology”

This case report describes a 3-year-old girl with short hair since birth, showing normal hair density with many vellus and intermediate hairs, and no hair shaft abnormalities.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

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This study found that topical minoxidil modestly extended the anagen phase in mice by activating β-catenin activity in dermal papilla cells.

research Phenotypic Variability Associated with WNT10A Nonsense Mutations

28 citations , February 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

This article reviews phenotypic variability linked to WNT10A nonsense mutations and does not present new research findings.

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

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This study found that previously undescribed WNT10A mutations are a prominent cause of various forms of ectodermal dysplasia, including OODD and Schöpf-Schulz-Passarge syndrome, with gender-specific phenotypic effects noted.

research Scratching the Surface of Skin Development

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research Short Anagen Syndrome

37 citations , July 2005 in “Journal of The American Academy of Dermatology”

This article reviews the clinicopathologic features of short anagen syndrome in a child and suggests diagnostic methods like clinical examination and scalp hair growth rate measurement, without reporting new clinical results.

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research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

research Congenital Hypotrichosis Due to Short Anagen Phase

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This report describes two children with congenital hypotrichosis and found their short hair is due to a shortened anagen phase, with the condition resolving spontaneously during puberty.