Coordinated Inhibition of SOX9 and Cell Cycle Progression by MicroRNA-200 Restricts Sebaceous Gland Fate Specification

    January 2026
    Arpan Das, Yuheng C Fu, Haimin Li … Rui Yi
    Studysummary This study reveals that the microRNA-200 family, highly enriched in hair matrix progenitors, restricts sebaceous gland development by inhibiting the SOX9-dependent lipogenic program, highlighting its specific role in epithelial plasticity within hair follicles.
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    Research cited in this study 15

    1. Gene Trajectory Inference For Single-Cell Data By Optimal Transport Metrics Nature Biotechnology · 2024
    2. Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury Cell Reports · 2023
    3. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    4. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    5. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity Cell reports · 2016
    6. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    7. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    8. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    9. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    10. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    11. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    12. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    13. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    14. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    15. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001