Hair Growth Promotion by Necrostatin-1s

October 2020 in “ Scientific Reports ”

Mei Zheng, Nahyun Choi, YaeJi Jang, Da Eun Kwak, Young Soo Kim, Won-Serk Kim, Sang Ho Oh, Jong-Hyuk Sung

Necrostatin-1s RIPK1 inhibitor outer-root sheath cells ORS cells hair follicle telogen phase anagen phase Wnt/β-catenin signaling pathway Wnt3a Wnt5b necroptosis RIPK3

Studysummary In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study found that Necrostatin-1s (Nec-1s), a RIPK1 inhibitor, effectively promoted hair growth by enhancing the proliferation and migration of human outer-root sheath (ORS) cells and increasing hair follicle length in mouse and pig organ cultures. Nec-1s accelerated the transition from the telogen to anagen phase and extended the anagen period in mice. It activated the Wnt/β-catenin signaling pathway, crucial for hair growth, by upregulating Wnt3a and Wnt5b mRNA expression. The study suggested that Nec-1s could be a potential treatment for hair loss by inhibiting necroptosis and activating hair growth pathways, as RIPK1 and RIPK3 were highly expressed during hair regression.

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