260 citations
,
June 2011 in “Cell” This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.
95 citations
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July 2010 in “Genes & development” In this study, the researchers reported that Notch/CSL signaling is crucial for hair follicle differentiation, with Wnt5a signaling and FoxN1 acting as mediators in mice.
7 citations
,
October 2022 in “Development” This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.
56 citations
,
January 2022 in “Burns & Trauma” This study suggests that intercellular communication via the WNT5A and STAT pathways may partly drive EMT-like phenomena in keloid pathogenesis, based on findings in an animal model.
19 citations
,
January 2013 in “International journal of medical sciences” In this study, overexpression of Wnt5a in mice was associated with the elongation of the telogen stage and inhibition of hair growth initiation, suggesting Wnt5a's role in maintaining hair follicle quiescence.