The Integrated Stress Response Fine-Tunes Stem Cell Fate Decisions Upon Serine Deprivation and Tissue Injury

    June 2025 in “ Cell Metabolism ”
    Jesse Novak, Lisa Polak, Sanjeethan C. Baksh … Elaine Fuchs
    Studysummary This study found that dietary serine levels influence hair follicle stem cells' ability to balance hair regeneration and wound repair, offering insights for potential interventions to accelerate wound healing.
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    Research cited in this study 13

    1. CD80 on Skin Stem Cells Promotes Local Expansion of Regulatory T Cells Upon Injury to Orchestrate Repair Within an Inflammatory Environment Immunity · 2024
    2. Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices Science · 2024
    3. Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer Nature Reviews Genetics · 2018
    4. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    5. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    6. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    7. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    8. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    9. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    10. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    11. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    12. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    13. Serine-Rich Ultra High Sulfur Protein Gene Expression in Murine Hair and Skin During the Hair Cycle Journal of Biological Chemistry · 1990