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GlossaryKeratin 1

protein providing structural support in skin cells

Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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research Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells

133 citations , March 1999 in “Journal of Cutaneous Pathology”

Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.

research Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia

54 citations , January 2009 in “British Journal of Dermatology”

Scarring alopecia affects different hair follicle stem cells than nonscarring alopecia, and the infundibular region could be a new treatment target.

research Mycobacterial 65,000 MW Heat-Shock Protein Shares a Carboxy-Terminal Epitope with Human Epidermal Cytokeratin 1/2

31 citations , October 1992 in “PubMed”

A mycobacterial protein shares a similar region with a human skin protein, possibly affecting skin diseases.

research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations , February 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research Cytokeratin 15 Expression in Central, Centrifugal, Cicatricial Alopecia: New Observations in Normal and Diseased Hair Follicles

14 citations , January 2011 in “Journal of Cutaneous Pathology”

CK15 is not a reliable marker for stem cells in damaged hair follicles from patients with CCCA.

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