Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

April 2018 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Chanat Kumtornrut, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba

androgens testosterone dihydrotestosterone estrogens amphiregulin epiregulin fibroblast growth factor 10 insulin-like growth factors keratinocyte proliferation keratinocyte differentiation tyrosine kinase inhibitors immunostaining dermal fibroblasts keratinocytes T DHT FGF10 IGFs

Studysummary This study found that testosterone and dihydrotestosterone can induce growth factors from dermal fibroblasts, promoting keratinocyte proliferation and differentiation, which may contribute to sex hormone-related acne development.

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