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research No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles

7 citations , March 2018 in “Experimental Dermatology”

This study found no evidence of increased keratinocyte proliferation in acne vulgaris, suggesting that other mechanisms may be responsible for hyperkeratinization in acne pathogenesis.

research Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling

August 2026 in “In Vivo”

This study found that DHT induces apoptosis in human keratinocyte cells via ERK activation, independently of androgen receptors and the Wnt/β-catenin pathway.

research PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis

12 citations , August 2022 in “Stem cell reviews and reports”

This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by interacting with SIRT1 and PARP1, highlighting a potential mechanism for addressing aging-related diseases.

research PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSC senescence and apoptosis

3 citations , April 2022 in “Research Square (Research Square)”

In this study, the researchers identified a PBX1-SIRT1-PARP1 axis that plays a crucial role in reducing senescence and apoptosis in hair follicle-derived mesenchymal stem cells.

research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

This study found that intrinsic reactive oxygen species drive the hair follicle cycle progression through DNA damage and repair, apoptosis, and macrophage polarization, influencing hair loss and regeneration dynamics in mice.

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community Ru58841 cleared my forehead acne

in Treatment 8 upvotes 1 year ago

RU58841 helped clear forehead acne. The user mixes it with 5% minoxidil and considers making a cream for acne treatment.

community Pyrilutamide cleared for phase 3 clinical trial in china

29 upvotes 4 years ago

Hair loss discussion includes Minoxidil, Finasteride, and RU58841 treatments. Pyrilutamide cleared for phase 3 clinical trial in China.

community Scalp inflammation cleared after stopping "spoiled" milk - what about follicles,shedding?

4 upvotes 6 months ago

Switching milk brands cleared scalp inflammation and other symptoms, but hair shedding continues. The user hopes shedding will stop as hair cycles progress.

community No more hair transplants - a new FDA-cleared fractional laser treatment called FoLix

105 upvotes 11 months ago

A new FDA-cleared fractional laser treatment called FoLix is discussed as a potential alternative to hair transplants, but users express skepticism due to its high cost, pain, and lack of proven results. Some users prefer traditional methods like Minoxidil, finasteride, steroid shots, and microneedling for hair growth.

community (Topical) Finasteride cleared my scalp from miniaturised hair (female).

in Finasteride/Dutasteride 50 upvotes 3 years ago

A female user's experience with topical and oral finasteride for hair loss, which has been successful as evidenced by the reduction of miniaturized hairs. Replies to the post discussed the recommended dosage for females versus males.

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