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research Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

40 citations , April 2014 in “Genes & Development”

The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.

Machine Learning-Guided Multi-Omics Suggests Iron-Dependent Hormonal Signaling Drives Root Morphological Plasticity in Wheat Under Temperature Stress

research Machine learning‐guided multi‐omics suggests iron‐dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress

June 2026 in “New Phytologist”

This study used multi-omics analysis to explore how wheat roots adapt to temperature stress, revealing that distinct hormonal signaling pathways are linked to iron homeostasis and drive root morphological changes, supporting the idea of an 'iron-dependent hormonal trade-off' model.

research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies

15 citations , June 2020 in “Experimental Dermatology”

This review discusses recent genetic findings on hormonal signaling pathways in androgenetic alopecia, reporting no new study results but highlighting the need for further investigation.

Xiaozhi Yufa Decoction Ameliorates Androgenetic Alopecia Through Inhibition of MAPK Signaling and Regulation of Lipid Metabolism

research Xiaozhi Yufa decoction ameliorates androgenetic alopecia through inhibition of MAPK signaling and regulation of lipid metabolism

November 2025 in “Frontiers in Pharmacology”

In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.

research Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

4 citations , June 2023 in “Frontiers in Aging”

This scoping review evaluates the connection between hypoxia and declining sex hormonal signaling in middle-aged individuals, proposing a "middle-aging hypovascularity hypoxia hypothesis" as a potential mechanism influencing age-related diseases, with implications for developing strategies to maintain healthspan.

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community The Real Reason For Hair Loss?

8 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Going off oral fin AND oral min when trying to conceive?

in Minoxidil 4 upvotes 4 weeks ago

A user is considering stopping oral finasteride and minoxidil while trying to conceive. Users suggest stopping finasteride to improve fertility but continuing minoxidil, as it is non-hormonal.

community I cannot even tolerate Nutrafol

in Product 6 upvotes 10 months ago

The user experienced side effects from finasteride and Nutrafol, opting for non-hormonal treatments like minoxidil, exercise, and a healthy lifestyle. Others discussed using Dutasteride, Biotin, and minoxidil with varying success and side effects.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

learn Stem Cell Factor

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Baicapil

Losing hair from hormonal imbalance? Baicapil might block DHT without messing with your hormones. No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is cancer cell-line work in which the effect was explicitly independent of the androgen receptor.

learn Adenosine

Adenosine : Can it help if my hair loss is due to a hormonal imbalance like PCOS or DHT? Adenosine may help improve hair growth affected by hormonal imbalances like PCOS or DHT.

learn Bicalutamide

Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

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