Hormonal Regulation and Systemic Signals of Skin Aging

The document from 2015 examines the influence of hormones on skin aging, noting that hormonal imbalances can lead to skin pathologies and that aging affects skin properties such as thickness, collagen organization, and wound healing. It discusses how hormones like estrogen and testosterone can impact skin health, with estrogen replacement shown to improve skin characteristics in postmenopausal women, and testosterone replacement potentially rejuvenating aged men's skin. The document also explores the role of growth factors like TGF-β in collagen production and wound healing, and how hormonal signals like NF-kB are associated with aging skin phenotypes. Clinical applications of hormonal modification are considered for promoting skin health during aging, but the document does not provide specific participant numbers for the referenced studies. It suggests that future skin aging treatments may benefit from advances in sequencing and stem cell biology, leading to more personalized approaches and a deeper understanding of hormonal skin regulation.