Dorsal Skin Reactions of Hairless Dogs to Topical Treatment with Corticosteroids

September 1999 in “ Toxicologic pathology ”

Tohru Kimura, Kunio Doi

corticosteroids topical treatment skin atrophy inflammation epidermal atrophy histologic changes

TLDR Stronger corticosteroids cause more skin damage in hairless dogs, similar to effects in humans.

The study from 1999 investigated the effects of continuous topical treatment with corticosteroids on the dorsal skin of hairless dogs, using four corticosteroids of varying potency. Results showed that stronger corticosteroids caused more significant skin atrophy and inflammation, with effects persisting post-treatment. Even weak corticosteroids led to notable epidermal atrophy. The histologic changes in the dogs mirrored those in humans and Yucatan hairless micropigs, suggesting that hairless dogs are a sensitive and useful model for studying the efficacy and adverse effects of topical corticosteroids.

View this study on journals.sagepub.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 58 results

community An argument for why we should take topical Dutasteride seriously

in Research/Science 85 upvotes 3 years ago

Topical Dutasteride may halt hair loss and effectively treat androgenic alopecia. Combining low-dose oral Dutasteride with topical application could maximize regrowth and minimize side effects.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community I’m on a crazy hairloss stack and I’m still losing hair and not experiencing any regrowth. What is going on?

in Treatment 30 upvotes 6 months ago

The user is using a combination of hair loss treatments including finasteride, stemoxydine, oral minoxidil, RU58841, dermastamping, ketoconazole shampoo, collagen, Viviscal, and biotin, and has improved their diet. Despite these efforts, they are still experiencing hair shedding and scalp itchiness, and are considering increasing their minoxidil dosage or starting dutasteride.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Hair came back in 3 months at 39y/o.

in Progress Pictures 421 upvotes 1 year ago

A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

community Treating my DUPA via controlling inflammation

in Treatment 6 upvotes 9 months ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

Related Research

1 / 1 results

Production of Ultraviolet-Light-Induced Skin Erythema in the Hairless Rat: A Comparison with the Haired Rat in Screening for Anti-Inflammatory Drugs

research Production of Ultraviolet-Light-Induced Skin Erythema in the Hairless Rat: A Comparison with the Haired Rat in Screening for Anti-Inflammatory Drugs

3 citations, October 1979 in “Laboratory animals”

Hairless rats are good for testing anti-inflammatory drugs, similar to haired rats, without needing to remove fur.