Dorsal Skin Reactions of Hairless Dogs to Topical Treatment with Corticosteroids

September 1999 in “ Toxicologic pathology ”

Tohru Kimura, Kunio Doi

corticosteroids topical treatment skin atrophy inflammation epidermal atrophy histologic changes

TLDR Stronger corticosteroids cause more skin damage in hairless dogs, similar to effects in humans.

The study from 1999 investigated the effects of continuous topical treatment with corticosteroids on the dorsal skin of hairless dogs, using four corticosteroids of varying potency. Results showed that stronger corticosteroids caused more significant skin atrophy and inflammation, with effects persisting post-treatment. Even weak corticosteroids led to notable epidermal atrophy. The histologic changes in the dogs mirrored those in humans and Yucatan hairless micropigs, suggesting that hairless dogs are a sensitive and useful model for studying the efficacy and adverse effects of topical corticosteroids.

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Production of Ultraviolet-Light-Induced Skin Erythema in the Hairless Rat: A Comparison with the Haired Rat in Screening for Anti-Inflammatory Drugs

research Production of Ultraviolet-Light-Induced Skin Erythema in the Hairless Rat: A Comparison with the Haired Rat in Screening for Anti-Inflammatory Drugs

3 citations, October 1979 in “Laboratory animals”

Hairless rats are good for testing anti-inflammatory drugs, similar to haired rats, without needing to remove fur.