Skin Signs of Systemic Diseases

The document reviewed the skin manifestations of various systemic diseases, highlighting the importance of skin examination in the early diagnosis and treatment of these conditions. It detailed the skin signs of diseases such as Ehlers-Danlos syndrome, Kawasaki disease, sarcoidosis, systemic lupus erythematosus, dermatomyositis, systemic sclerosis, Raynaud disease, rheumatoid arthritis, and Sjögren syndrome. Specific examples included scurvy presenting with hyperkeratotic papules and alopecia, and diabetes mellitus leading to conditions like acanthosis nigricans. Hyperthyroidism and hypothyroidism were associated with a range of skin symptoms, including alopecia and hair loss, while Cushing syndrome and Addison disease were noted for skin atrophy and hyperpigmentation, respectively. The document aimed to assist healthcare professionals in recognizing these skin signs to prevent severe progression of the underlying diseases. No specific study population was mentioned as the document was a clinical feature review rather than an empirical study.