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GlossaryAdrenal Insufficiency (Addison's disease)

occurs when adrenal glands produce insufficient cortisol and aldosterone

Adrenal Insufficiency, also known as adrenal failure or adrenal hypofunction, is a condition where the adrenal glands do not produce enough of certain hormones, particularly cortisol and sometimes aldosterone. This can lead to symptoms such as fatigue, muscle weakness, weight loss, low blood pressure, and skin changes. It can be caused by autoimmune disorders, infections, or other underlying health issues, and requires medical diagnosis and management.

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research Histopathologic Findings of Cutaneous Hyperpigmentation in Addison's Disease and Immunostain of the Melanocytic Population

9 citations, June 2017 in “The American journal of dermatopathology/American journal of dermatopathology”

The study found increased skin pigmentation and variable melanocyte density in a patient with Addison's disease.

research Skin Signs of Systemic Diseases

21 citations, August 2011 in “Clinics in Dermatology”

Looking at skin can help find and treat serious diseases early.

research Skin Diseases Due to Endocrine Alterations

16 citations, January 2006 in “The Aging Male”

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

research Addisonian Crisis in a Young Man with Atypical Anorexia Nervosa

13 citations, December 2010 in “Nature Reviews Endocrinology”

A young man with an eating disorder had a life-threatening adrenal crisis due to an autoimmune condition, highlighting the need for better education on managing hormone treatments.

research The Skin and Subcutaneous Tissues: Conditions, Diagnosis, and Systemic Implications

1 citations, January 2013 in “Springer eBooks”

The document concludes that skin and nail changes can indicate various underlying health conditions.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.