Cutaneous Manifestations of Metabolic Diseases: Uncommon Presentations

    September 2005 in “ Clinics in Dermatology ”
    E Köstler, H. Porst, Uwe Wollina
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    TLDR Some skin problems can be signs of diabetes or other metabolic diseases and recognizing them can help diagnose and treat these diseases early.
    The document reviewed skin manifestations associated with metabolic diseases, particularly noting that about one-third of diabetic patients develop skin conditions that may signal the onset or complications of diabetes. These conditions include a range of symptoms such as erythema, pigmentary changes, and hair and nail abnormalities. The paper also covered skin signs of other metabolic disorders like lipid metabolism issues, gout, and zinc metabolism disorders, highlighting their diagnostic importance. Specific conditions such as acrodermatitis enteropathica, Menkes syndrome, Wilson disease, oxalosis, and mucopolysaccharidoses were mentioned, each with unique cutaneous presentations like alopecia, kinky hair, and hyperpigmentation. The document underscored the clinical significance of recognizing these signs for early diagnosis and management of the underlying metabolic disease.
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