Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia

September 2023 in “ Medicina-lithuania ”

Mariana Păun, Gustavo Torres, George Sorin Țiplica, V. Cauni

non-cicatricial alopecia androgenetic alopecia alopecia areata GR-alpha GPR44-2 SULT1A1 CRABP2 minoxidil SRD5A1 PTGFR-2 Dutasteride Latanoprost SNPs DNA analysis AGA AA Rogaine

TLDR The study suggests that analyzing DNA can help treat hair loss, but more research is needed.

The study examined the distribution of specific genes in 287 Romanian and 882 Brazilian patients with non-cicatricial alopecia, specifically androgenetic alopecia (AGA) and alopecia areata (AA). It found significant differences in the distribution of the GR-alpha, GPR44-2, SULT1A1, and CRABP2 genes between the two populations. The SULT1A1 gene, which predicts response to minoxidil treatment, suggested that minoxidil is recommended in half of the AGA and AA cases. Patients with AGA and high expression of SRD5A1 or PTGFR-2 may benefit from Dutasteride or Latanoprost treatment, respectively. The study also identified five specific SNPs with potential relevance in the genetic basis of alopecia. The study concluded that DNA analysis of patients with alopecia may contribute to successful treatment, but further extensive studies are necessary to confirm these findings.

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