Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia

The study examined the distribution of specific genes in 287 Romanian and 882 Brazilian patients with non-cicatricial alopecia, specifically androgenetic alopecia (AGA) and alopecia areata (AA). It found significant differences in the distribution of the GR-alpha, GPR44-2, SULT1A1, and CRABP2 genes between the two populations. The SULT1A1 gene, which predicts response to minoxidil treatment, suggested that minoxidil is recommended in half of the AGA and AA cases. Patients with AGA and high expression of SRD5A1 or PTGFR-2 may benefit from Dutasteride or Latanoprost treatment, respectively. The study also identified five specific SNPs with potential relevance in the genetic basis of alopecia. The study concluded that DNA analysis of patients with alopecia may contribute to successful treatment, but further extensive studies are necessary to confirm these findings.