Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia

September 2023 in “ Medicina-lithuania ”

Mariana Păun, Gustavo Torres, George Sorin Țiplica, V. Cauni

non-cicatricial alopecia androgenetic alopecia alopecia areata GR-alpha GPR44-2 SULT1A1 CRABP2 minoxidil SRD5A1 PTGFR-2 Dutasteride Latanoprost SNPs DNA analysis AGA AA Rogaine

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary In this study, DNA analysis of patients with androgenetic alopecia and alopecia areata indicated potential differences in treatment response based on genetic makeup across Romanian and Brazilian populations, notably involving genes like GR-alpha and SULT1A1, which may guide personalized treatment strategies. Our plain-language summary of this paper — not a Tressless recommendation.

The study examined the distribution of specific genes in 287 Romanian and 882 Brazilian patients with non-cicatricial alopecia, specifically androgenetic alopecia (AGA) and alopecia areata (AA). It found significant differences in the distribution of the GR-alpha, GPR44-2, SULT1A1, and CRABP2 genes between the two populations. The SULT1A1 gene, which predicts response to minoxidil treatment, suggested that minoxidil is recommended in half of the AGA and AA cases. Patients with AGA and high expression of SRD5A1 or PTGFR-2 may benefit from Dutasteride or Latanoprost treatment, respectively. The study also identified five specific SNPs with potential relevance in the genetic basis of alopecia. The study concluded that DNA analysis of patients with alopecia may contribute to successful treatment, but further extensive studies are necessary to confirm these findings.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

31 / 31 results

research The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth

October 2022 in “The Korean Journal of Physiology and Pharmacology”

This review discusses the roles of prostaglandins in hair loss and highlights their potential as targets for new alopecia treatments, but reports no new clinical findings.

research The Effect of Latanoprost 0.005% Solution in the Management of Scalp Alopecia Areata: A Randomized Double-Blind Placebo-Controlled Trial

2 citations , March 2022 in “Dermatologic Therapy”

This study found that using topical latanoprost 0.005% solution significantly increased hair density and regrowth in patients with scalp alopecia areata over 12 weeks, although it did not significantly reduce hair loss area compared to the placebo.

research Alopecia Areata: Current Understanding and Management

11 citations , January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft”

This review discusses current and emerging therapies for alopecia areata, highlights the challenges in managing this chronic disease, and emphasizes the importance of addressing its psychosocial impacts; it reports no new clinical results.

Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia

research Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia

November 2020 in “Postepy Dermatologii I Alergologii”

This review discusses the potential of using SULT1A1 expression in the scalp as a biomarker to predict response to minoxidil treatment for androgenetic alopecia, but reports no new clinical results.

research Genetic Variations Associated With Response to Dutasteride in the Treatment of Male Subjects With Androgenetic Alopecia

3 citations , September 2019 in “PLOS ONE”

In this study, the authors identified the DHRS9 SNP rs72623193 as most significantly associated with response to dutasteride in treating male pattern hair loss, with additional variants potentially contributing.

research The Effect of Topical Minoxidil Treatment on Follicular Sulfotransferase Enzymatic Activity

4 citations , May 2019 in “PubMed”

This study reported that the expression of sulfotransferase enzymes in hair follicles remained stable during treatment with topical minoxidil, indicating consistent metabolic activity throughout the treatment period.

research Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2 citations , February 2019 in “Journal of Investigative Dermatology”

This study suggests that the expression of the DP2 receptor is higher in balding scalp cells and that its knockdown could inhibit the transition to the catagen phase in cultured human hair follicles, potentially counteracting hair growth inhibition associated with male pattern baldness.

research Prostaglandins in Androgenetic Alopecia in 12 Men and Four Women

8 citations , February 2019 in “Journal of The European Academy of Dermatology and Venereology”

This letter to the editor about prostaglandins in androgenetic alopecia in men and women reports no new research findings.

research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

18 citations , February 2018 in “International Journal of Molecular Sciences”

This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.

research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

27 citations , April 2017 in “British Journal of Dermatology”

This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.

research A Review of the Use of Biotin for Hair Loss

78 citations , January 2017 in “Skin appendage disorders”

This review discusses the use of biotin for hair and nail growth, noting clinical improvement in cases with existing pathologies, but concludes there is insufficient evidence supporting its benefits for healthy individuals.

research Lisinopril-Induced Alopecia: A Case Report

8 citations , June 2016 in “Journal of Pharmacy Practice”

This case report suggests that lisinopril may cause alopecia, which resolved after the patient switched to losartan potassium.

research Prediction of Male-Pattern Baldness from Genotypes

37 citations , October 2015 in “European Journal of Human Genetics”

This study found that a genetic model using SNPs can predict early-onset male-pattern baldness with moderate accuracy, which may assist in decisions about interventions.

research The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments

62 citations , January 2015 in “Journal of Dermatological Science”

This review summarizes the current genetic research on alopecia areata, including potential new therapeutic strategies, but reports no new clinical findings.

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

27 citations , February 2014 in “Experimental Dermatology”

This study found that dermal papilla cells from balding scalp follicles secrete significantly less insulin-like growth factor-1 and its binding proteins, suggesting a mechanism contributing to male pattern baldness.

research Association of HSPA1B SNP rs6457452 With Alopecia Areata in the Korean Population

12 citations , December 2013 in “Immunological Investigations”

This study suggests that the 5’UTR SNP rs6457452 of HSPA1B may be associated with the onset of Alopecia Areata and reduced susceptibility in the Korean population.

research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women

19 citations , May 2013 in “Annals of Oncology”

This study observed that aromatase inhibitors caused hair loss in menopausal women with breast cancer, mimicking male pattern baldness rather than female androgenetic alopecia.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that dexamethasone treatment reduced cell viability and growth factor expression in human dermal papilla cells, suggesting it inhibits hair growth.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Investigation of Variants of the Aromatase Gene (CYP19A1) in Female Pattern Hair Loss

15 citations , June 2011 in “British Journal of Dermatology”

This study observed a potential association between the CC genotype of rs4646 and female pattern hair loss, but the authors advise caution due to lack of experiment-wide significance and recommend replication.

research Male Androgenetic Alopecia

100 citations , April 2010 in “Expert Opinion on Pharmacotherapy”

This article reviews existing treatments for male-pattern hair loss, noting that while they can slow progression, they generally achieve only partial hair regrowth.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , April 2009 in “British Journal of Dermatology”

In this study, genetic variation in the CYP19A1 gene, particularly the common rs4646 C allele, was associated with an increased risk of female pattern hair loss, especially in women under 40.

research Prostanoid Receptors in Anagen Human Hair Follicles

39 citations , November 2007 in “Experimental dermatology”

This study found that prostaglandin receptors are widely expressed in hair follicles, suggesting a complex network of prostanoid pathways involved in hair growth control.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased scalp hair growth in men with male pattern hair loss, particularly at a 2.5 mg dose, and was more effective than finasteride over 24 weeks.

research Androgenetic Alopecia in Women

139 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.

research Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia

15 citations , April 2003 in “Journal of Dermatological Science”

This study found no significant associations between the polymorphisms of SRD5A1 and SRD5A2 genes and androgenetic alopecia, clinical types of baldness, or response to finasteride in Koreans.