Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia

August 2007 in “ British Journal of Dermatology ”

Robert Sinclair, Karen J. Greenland, S. van Egmond, Caroline Hoedemaker, A. Chapman, Jeffrey D Zajac

TLDR Men with Kennedy disease have less chance of hair loss.

Men with Kennedy disease (KD) have a reduced risk of developing androgenetic alopecia (AGA), according to a study. The KD cohort had thicker hair than the control population, and age was not associated with hair loss in the KD cohort. The study supports the hypothesis that functional changes in androgen receptor expression, which lead to a diminished effect of androgens, contribute to a reduced risk of AGA in men with KD.

View this study on academic.oup.com →

Discuss this study in the Community →

Cited in this study

9 / 9 results

research Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

23 citations , December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride works better for baldness in people with shorter gene repeats.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations , December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

76 citations , April 2005 in “Cancer Epidemiology, Biomarkers & Prevention”

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.