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Glossary Kennedy's Disease

x-linked genetic disorder causing muscle weakness and atrophy

Kennedy's Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a rare, X-linked genetic disorder that primarily affects males. It is characterized by the progressive degeneration of motor neurons in the spinal cord and brainstem, leading to muscle weakness, atrophy, and sometimes endocrine disturbances such as gynecomastia and reduced fertility.

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Research

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research Men with Kennedy disease have a reduced risk of androgenetic alopecia

41 citations , June 2007 in “British Journal of Dermatology”

This study found that men with Kennedy disease have a significantly lower risk of androgenetic alopecia, likely due to androgen receptor gene alterations from the disease's polyglutamine expansion.

research Perspectives of Kennedy's disease

65 citations , September 2010 in “Journal of the Neurological Sciences”

This article discusses Kennedy's disease, detailing its genetic cause, symptoms, and diagnostic criteria, but reports no new clinical findings and highlights a lack of causal therapy.

research Kennedy's disease and partial androgen insensitivity syndrome. Report of 4 cases and literature review

May 2015 in “Endocrinología y nutrición”

This study described four adult male cases of Kennedy disease with typical neurological symptoms and noted gynecomastia as the most frequent endocrinological manifestation, accompanied by an abnormal expansion in the androgen receptor gene.

research In response to the letter to the editor by Soha Ghanian et al. re our publication “Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males”

June 2021 in “EBioMedicine”

This paper reports no new results; it addresses the effects of Dutasteride on testosterone and DHT in men, and discusses the implications for androgen deprivation and COVID-19 outcomes.

research Significance of the polyglutamine tract polymorphism in the androgen receptor

54 citations , November 2001 in “Urology”

This review discusses the association between androgen receptor CAG repeat polymorphism and several health conditions, including Kennedy’s disease and urologic disorders, without reporting new clinical results.

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