The Roles of Wnt/β-Catenin Pathway in Tissue Development and Regenerative Medicine

    November 2017 in “ Journal of Cellular Physiology ”
    Maryam Majidinia, Javad Akhondian, Rana Jahanban‐Esfahlani, Bahman Yousefi
    Image of study
    TLDR The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.
    The 2018 review article outlined the significant role of the Wnt/β-catenin signaling pathway in tissue development and regenerative medicine. It emphasized the pathway's involvement in regulating cell fate, proliferation, and maintenance of stem and cancer stem cells, as well as its contribution to the development and regeneration of various tissues such as the heart, lung, liver, bone, cartilage, kidney, skeletal muscle, and hair follicles. The document highlighted the pathway's dual effects, such as promoting cell proliferation at low signaling levels and suppressing it at high levels, and its varying impact on different tissues, including both positive and negative effects on cardiac repair, lung epithelial cell injury, and kidney repair. The review also discussed the therapeutic potential of modulating the Wnt/β-catenin pathway, including the use of small molecule inhibitors for treating diseases like cancer and fibrosis, and the importance of macrophages in kidney regeneration. It concluded that while the Wnt/β-catenin pathway is crucial for regenerative medicine, more research is needed to optimize its targeting for effective therapies.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 60 results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 5 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  6 upvotes 1 year ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 2 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

    Related Research

    1 / 1 results