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    Glossary Stem Cell Depletion

    reduction of stem cells impairing tissue regeneration and repair

    Stem cell depletion refers to the reduction or exhaustion of stem cells in a particular tissue or organ. This can lead to impaired tissue regeneration and repair, contributing to aging and various diseases, including hair loss conditions like alopecia. For professionals, it highlights the importance of maintaining stem cell populations for tissue homeostasis and the potential therapeutic targets for regenerative medicine.

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    1. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis Cell Stem Cell · 2021 · 23 citations
    2. Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood Journal of Investigative Dermatology · 2007 · 18 citations
    3. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    4. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011 · 54 citations
    5. Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying Cell Regeneration · 2025
    6. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    7. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    8. LB965 Follicular trochanters: A potential mechanism for stem cell depletion in scarring alopecia 2020
    9. Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling Scientific Reports · 2017 · 22 citations
    10. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    11. Faculty Opinions recommendation of Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    12. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    13. Ox40-Cre–mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia JCI insight · 2022 · 1 citations
    14. Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals Carcinogenesis · 2015 · 11 citations
    15. Inducible deletion of epidermal <i>Dicer</i> and <i>Drosha</i> reveals multiple functions for miRNAs in postnatal skin Development · 2012 · 82 citations
    16. 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics Journal of Investigative Dermatology · 2025
    17. 743 Adipocyte stem cells are maintained by Pdgfα signaling in the skin Journal of Investigative Dermatology · 2016
    18. A cell polarity protein, aPKCλ, is essential for maintaining hair follicle stem cell quiescence and hair follicle regeneration Journal of Dermatological Science · 2016
    19. Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition Communications biology · 2024
    20. Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes The Journal of Steroid Biochemistry and Molecular Biology · 2026
    21. Faculty Opinions recommendation of GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    22. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation Journal of Clinical Investigation · 2011 · 20 citations
    23. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    24. Apoptotic dysregulation mediates stem cell competition and tissue regeneration Nature Communications · 2023
    25. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015 · 24 citations
    26. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    27. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    28. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth Pflügers Archiv - European Journal of Physiology · 2022
    29. The homing of exogenous hair follicle mesenchymal stem cells into hair follicle niches JCI Insight · 2023 · 6 citations
    30. <i>N</i>1-acetylspermidine is a determinant of hair follicle stem cell fate Journal of Cell Science · 2021 · 17 citations