Age-Related Hair Pigment Loss

Age-related hair pigment loss, or graying, served as a visible indicator of aging and was influenced by the hair growth cycle, which regulated follicular melanocytes. Research on mice suggested that melanocyte stem cell depletion contributed to graying, but caution was advised when applying these findings to humans. Both species likely experienced an age-related imbalance in oxidative stress management, affecting melanogenesis and melanocyte health. Emerging evidence indicated that the hair follicle pigmentary unit might have regenerative potential, suggesting possible strategies to prolong melanin production and delay graying.