TCDD-Induced Activation of Aryl Hydrocarbon Receptor Regulates the Skin Stem Cell Population

    January 2015 in “ Medical hypotheses ”
    Chirag Mandavia
    Studysummary This report suggests that TCDD may alter human epidermal stem cell populations by upregulating c-Myc, potentially leading to increased stem cell turnover during chloracne development.
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    Research cited in this study 3

    1. Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice EMBO molecular medicine · 2014
    2. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    3. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011

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