Major Depletion of SOX2+ Stem Cells in the Adult Pituitary Is Not Restored and Does Not Affect Hormonal Cell Homeostasis and Remodeling

    November 2017 in “ Scientific Reports ”
    Heleen Roose, Benoit Cox, Matteo Boretto, Conny Gysemans, Annelies Vennekens, Hugo Vankelecom
    Image of study
    TLDR The pituitary gland functions normally even after losing most SOX2+ stem cells.
    The study examined the effects of depleting SOX2+ stem cells in the adult pituitary gland and found that an 80% reduction of these cells did not lead to their repopulation. Despite this significant depletion, the maintenance of pituitary hormonal cell populations and their response to adrenalectomy were unaffected, indicating that SOX2+ cells might not be essential for endocrine cell homeostasis or remodeling. The findings suggested that the pituitary gland could maintain its function and structure even with a major loss of SOX2+ stem cells, highlighting the gland's resilience and adaptability. Further research was needed to clarify the specific roles of SOX2+ cells in the pituitary.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results