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Glossary Diabetic Ulcers

open sores on feet due to diabetes-related complications

Diabetic ulcers, also known as diabetic foot ulcers, are open sores or wounds that occur in individuals with diabetes, typically on the feet. These ulcers result from a combination of factors such as poor blood circulation, neuropathy (nerve damage), and a weakened immune system, which impair the body's ability to heal. If left untreated, diabetic ulcers can lead to serious complications, including infections and, in severe cases, amputation.

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Research

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research Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

90 citations , October 2023 in “Advanced Drug Delivery Reviews”

This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.

research Skin microbiota and diabetic foot ulcers

6 citations , July 2025 in “Frontiers in Microbiology”

This study observed that in patients with diabetic foot ulcers, an imbalance in skin microbiota, with increased pathogenic bacteria, contributes to infection and poor wound healing, and suggests that modulating microbiota composition might improve healing outcomes.

research Comparative Assessment of Topical Platelet-Rich Plasma and Phenytoin for Diabetic Foot Ulcer Healing in a Rat Model

June 2026 in “University of Science and Technology Journal for Medical Sciences”

In this study, both platelet-rich plasma gel and 1% phenytoin cream showed comparable results for wound healing in diabetic foot ulcers in rats, with PRP providing slightly advanced histological improvements; however, the differences were not statistically significant.

research 1492 Prostacyclin pathway to enhance wound healing in diabetic foot ulcers

April 2023 in “Journal of Investigative Dermatology”

This study found that treprostinil, a prostacyclin analog, significantly delayed fibroblast migration from healthy donors but did not affect fibroblast migration derived from diabetic foot ulcers.

research Exosome-based cell therapy for diabetic foot ulcers: Present and prospect

9 citations , October 2024 in “Heliyon”

In this review, the authors discuss the promising role of exosomes from various cell sources as potential cell-free therapies for diabetic foot ulcers, highlighting their therapeutic benefits in wound healing and the challenges faced in their clinical application.

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