56 citations
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March 2016 in “International Wound Journal” This review concludes that autologous split-thickness skin grafting remains the gold standard for safety and efficacy in treating chronic leg ulcers, with greater success in venous ulcers.
February 2009 in “Journal of The American Academy of Dermatology” A man with Klinefelter syndrome had a leg ulcer that didn't heal well, even with treatment.
99 citations
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July 1996 in “Journal of Investigative Dermatology” Using patient's own hair cells can effectively heal chronic leg ulcers.
63 citations
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October 2012 in “Wound Repair and Regeneration” This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.
3 citations
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January 2020 in “Journal of Cutaneous and Aesthetic Surgery” This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.