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    Glossary Chronic Leg Ulcers

    long-lasting leg sores that don't heal within six weeks

    Chronic leg ulcers are long-lasting sores or wounds on the legs that fail to heal within a typical timeframe, usually defined as six weeks or more. They are often caused by underlying conditions such as poor blood circulation, diabetes, or venous insufficiency, and can lead to significant pain, infection, and reduced quality of life if not properly managed.

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    1. Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine International Wound Journal · 2016 · 56 citations
    2. Klinefelter syndrome and chronic leg ulcers Journal of The American Academy of Dermatology · 2009
    3. Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells Journal of Investigative Dermatology · 1996 · 99 citations
    4. A pilot clinical study of hair grafting in chronic leg ulcers Wound Repair and Regeneration · 2012 · 63 citations
    5. Autologous smashed follicular dermal graft with epidermal cell suspension in chronic nonhealing leg ulcers Journal of Cutaneous and Aesthetic Surgery · 2020 · 3 citations
    6. Hair-follicle Transplant Into Chronic Ulcers: A New Graft Concept 2017 · 6 citations
    7. Ankle Range of Motion, Leg Pain, and Leg Edema Improvement in Patients With Venous Leg Ulcers JAMA Dermatology · 2016 · 4 citations
    8. Regeneration of Chronic Wounds with Allogeneic Platelet Gel versus Hydrogel Treatment: a Prospective Study Acta Clinica Croatica · 2018 · 25 citations
    9. Topical application of cellulose membrane for the treatment of non-healing venous leg ulcers Frontiers in Bioengineering and Biotechnology · 2026
    10. Hair follicle stem cells: Walking the maze European Journal of Cell Biology · 2007 · 165 citations
    11. Reflections on how wound healing-promoting effects of the hair follicle can be translated into clinical practice Experimental Dermatology · 2014 · 43 citations
    12. Proceedings of the 7thworld congress of hair research International Journal of Trichology · 2013 · 1 citations
    13. Stem Cells in the Skin 2016
    14. Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety Gyemyeong uidae haksulji · 2025 · 3 citations
    15. Self-Assessment Elsevier eBooks · 2019
    16. Obesity and the skin: Skin physiology and skin manifestations of obesity Journal of The American Academy of Dermatology · 2007 · 405 citations
    17. LB1154 Rising antimicrobial resistance in chronic wounds Journal of Investigative Dermatology · 2025
    18. Editor's Picks August 2023 Journal of the European Academy of Dermatology and Venereology · 2023
    19. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective International Journal of Molecular Sciences · 2023 · 188 citations
    20. Lead, Mercury, and Arsenic Poisoning Due to Topical Use of Traditional Chinese Medicines ˜The œAmerican journal of medicine · 2013 · 68 citations
    21. The Efficacy of Local Autologous Platelet-Rich Plasma Prepared by Single and Double Spin Methods in the Treatment of Chronic Ulcer Cureus · 2024 · 2 citations
    22. 527 PTEN is a master driver of healing inhibition in venous leg ulcers by targeting immune response, angiogenesis and lymphangiogenesis Journal of Investigative Dermatology · 2024
    23. Adjunctive treatment for leg ulcers Indian dermatology online journal · 2014
    24. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    25. Interrelation of immunity and tissue repair or regeneration Seminars in Cell & Developmental Biology · 2009 · 252 citations
    26. Zinc in skin pathology and care Journal of Dermatological Treatment · 2006 · 35 citations
    27. Innovative Uses for Zinc in Dermatology Dermatologic Clinics · 2010 · 27 citations
    28. Skin disorders in elderly subjects International Journal of Dermatology · 2015 · 27 citations
    29. Dermatology 2004 · 1 citations
    30. Skin Elsevier eBooks · 2011 · 2 citations