Klinefelter Syndrome and Chronic Leg Ulcers

The document reports on a 56-year-old male patient with Klinefelter syndrome who presented with a chronic nonhealing leg ulcer. Despite various treatments, including antibiotics and hyperbaric oxygen, the ulcer showed little improvement. The patient's medical history included hyperlipidemia and depression, and he exhibited physical characteristics such as a eunuchoid body habitus, scant facial and body hair, and small testicles. Laboratory tests revealed low testosterone and elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. Chromosome analysis confirmed a 47, XXY karyotype, diagnostic of Klinefelter syndrome. Subsequently, the patient began treatment with testosterone injections. This case study highlights the association between Klinefelter syndrome and chronic leg ulcers.