KY19382 Accelerates Cutaneous Wound Healing Via Activation Of The Wnt/β-Catenin Signaling Pathway

    July 2023 in “ International Journal of Molecular Sciences ”
    Minguen Yoon, Eunhwan Kim, Seol Hwa Seo … Kang‐Yell Choi
    Studysummary This study found that KY19382, a small molecule activating the Wnt/β-catenin pathway, significantly improved wound healing by enhancing cell migration, increasing collagen and stem cell markers, and accelerating re-epithelialization and neo-epidermis formation in a murine model without causing significant cytotoxicity.
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    Research cited in this study 9

    1. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    2. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    3. Wnt/β-Catenin Pathway in Tissue Injury: Roles in Pathology and Therapeutic Opportunities for Regeneration The FASEB Journal · 2016
    4. Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications International journal of molecular sciences · 2015
    5. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing Organogenesis · 2015
    6. Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately Stem Cell Research & Therapy · 2015
    7. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    8. Nestin-Expressing Interfollicular Blood Vessel Network Contributes to Skin Transplant Survival and Wound Healing Journal of Cellular Biochemistry · 2010
    9. Exploring the Role of Stem Cells in Cutaneous Wound Healing Experimental Dermatology · 2009