KY19382 Accelerates Cutaneous Wound Healing Via Activation Of The Wnt/β-Catenin Signaling Pathway

The study investigates the effects of KY19382, a small molecule that activates the Wnt/β-catenin signaling pathway, on cutaneous wound healing. KY19382 enhances cell migration in human keratinocytes and dermal fibroblasts, increasing levels of β-catenin and other markers without significant cytotoxicity. In a murine model, KY19382 significantly increased levels of Collagen I, Keratin 14, and stem cell markers, accelerating re-epithelialization and neo-epidermis formation. The findings suggest that KY19382 could be a promising candidate for developing new wound healing therapies by targeting the Wnt/β-catenin pathway.