Molecular Signaling Pathways in Wound-Induced Hair-Follicle Neogenesis

    March 2025 in “ Cells
    Soung‐Hoon Lee
    TLDR Understanding wound healing and signaling pathways could lead to new alopecia treatments.
    The article explores wound-induced hair-follicle neogenesis (WIHN), a process where new hair follicles regenerate from wounds, which could be significant for treating alopecia. WIHN is influenced by factors like wound size, age, and molecular signaling pathways, including Wnt and sonic hedgehog (SHH) signaling. Large wounds and younger age enhance WIHN, but practical application in humans is challenging. Key pathways such as IGF1, BMP, and HIF-1α, along with specific stem and immune cells, play crucial roles. Despite challenges, advancements in understanding these mechanisms and drug development, particularly targeting Wnt signaling, hold promise for effective alopecia treatments.
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