Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling

July 2023 in “ Pharmaceutics ”

Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang‐Yell Choi

Pyruvate kinase M2 PKM2 glycolysis Wnt/β-catenin signaling TEPP-46 KY19382 keratinocyte migration PCNA keratin 14 α-SMA angiogenesis

TLDR Activating PKM2 and Wnt/β-catenin signaling speeds up wound healing.

The study explores the role of Pyruvate Kinase M2 (PKM2) in cutaneous wound healing, focusing on its involvement in glycolysis and Wnt/β-catenin signaling. Using C3H mice and human keratinocytes, researchers found that activating PKM2 with TEPP-46 enhances wound healing by increasing pyruvate kinase activity, cell migration, and collagen deposition. The combination of TEPP-46 and the Wnt/β-catenin signaling activator KY19382 further accelerates healing and angiogenesis, suggesting that dual activation of these pathways could be an effective therapeutic strategy for enhancing wound repair.

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Research cited in this study

6 / 6 results

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research Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

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Activating PKM2 and Wnt/β-catenin signaling together can potentially enhance hair growth and could be a treatment for hair loss.

research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

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KY19382 helps regrow hair and create new hair follicles.

research Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities

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The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

research Wound Repair at a Glance

733 citations , September 2009 in “Journal of Cell Science”

Wound healing is a complex, multi-phase process involving various cells and activities to repair skin damage.

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