Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

May 2023 in “ Skin research and technology ”

Areum Won, Sooho Choi, A‐Ru Kim, Jeong Ho Hong

DNA aptamer WD-aptamer Wnt/β-catenin signaling human hair follicle dermal papilla cells HFDPCs CXXC5 Dishevelled1 Dvl1 Wnt3a β-catenin cell proliferation MTT assay Wnt signaling hair follicle cells hair growth

Studysummary This study found that WD-aptamer increased β-catenin expression and promoted human hair follicle dermal papilla cell proliferation by interfering with the CXXC5-Dvl1 interaction in the Wnt signaling pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrates that a DNA aptamer (WD-aptamer) can enhance Wnt/β-catenin signaling in human hair follicle dermal papilla cells (HFDPCs) by blocking the negative regulation mediated by CXXC5. This results in a significant increase in cell proliferation, with a 123.98% increase at a 5 μM concentration compared to the control. The findings indicate that WD-aptamer has potential as a therapeutic agent for hair regrowth by promoting dermal papilla cell activity and hair follicle development.

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Research cited in this study

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research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations , March 2021 in “British Journal of Pharmacology”

This study found that KY19382 can effectively promote hair regeneration and follicle neogenesis in mice and human hair models by activating Wnt/β-catenin signalling, suggesting potential use for alopecia treatment.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

This review discusses the role of Wnt/β-catenin signaling in hair follicle regeneration and highlights recent progress in developing hair loss treatments targeting this pathway, but reports no new clinical results.

research The Negative Regulator CXXC5: Making WNT Look a Little Less Disheveled

8 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that inhibiting the interaction between CXXC5 and Dishevelled could stimulate hair regrowth in mouse models by enhancing WNT/β-catenin signaling, suggesting a potential therapeutic strategy for hair loss involving compounds that block this interaction, such as interfering short peptides.

research Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

37 citations , June 2017 in “Journal of Investigative Dermatology”

This study suggests that the interaction between CXXC5 and Dishevelled is a potential target for promoting hair regrowth and hair follicle formation, offering a new approach to treat hair loss.

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

149 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

This article provides contact information for Bruce A. Morgan and features no new research findings.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.