Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

    May 2023 in “ Skin research and technology ”
    Areum Won, Sooho Choi, A‐Ru Kim, Jeong Ho Hong
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    TLDR A DNA aptamer helps promote hair growth by enhancing a key cell growth signal in hair follicle cells.
    The study demonstrates that a DNA aptamer (WD-aptamer) can enhance Wnt/β-catenin signaling in human hair follicle dermal papilla cells (HFDPCs) by blocking the negative regulation mediated by CXXC5. This results in a significant increase in cell proliferation, with a 123.98% increase at a 5 μM concentration compared to the control. The findings indicate that WD-aptamer has potential as a therapeutic agent for hair regrowth by promoting dermal papilla cell activity and hair follicle development.
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