Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

    May 2023 in “ Skin research and technology ”
    Areum Won, Sooho Choi, A‐Ru Kim, Jeong Ho Hong
    Image of study
    TLDR A DNA aptamer helps promote hair growth by enhancing a key cell growth signal in hair follicle cells.
    The study demonstrates that a DNA aptamer (WD-aptamer) can enhance Wnt/β-catenin signaling in human hair follicle dermal papilla cells (HFDPCs) by blocking the negative regulation mediated by CXXC5. This results in a significant increase in cell proliferation, with a 123.98% increase at a 5 μM concentration compared to the control. The findings indicate that WD-aptamer has potential as a therapeutic agent for hair regrowth by promoting dermal papilla cell activity and hair follicle development.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 121 results

      community DNA Testing by Roots by Genetic Arts

      in Research/Science  3 upvotes 8 months ago
      A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

      community Topical Melatonin for mild aga

      in Chat  2 upvotes 8 months ago
      The conversation is about an 18-year-old male considering topical finasteride for hair loss and asking about the effectiveness of topical melatonin for hair regrowth and density. No specific treatments were confirmed to be used.

      community Bryan Johnson used a customized formula by Roots byGA to restore his hair

      in Treatment  23 upvotes 3 weeks ago
      Bryan Johnson used a customized hair restoration formula from Roots byGA, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. Many users are skeptical of the effectiveness and uniqueness of the treatment, suggesting that standard treatments like Minoxidil and Dutasteride are more reliable.

      community Average tressless user after taking oral minoxidil

      in Satire  1446 upvotes 1 year ago
      The conversation is about hair loss and the use of minoxidil (Minoxidil) and finasteride (Fin) as treatments. The conclusion is that some users have seen success in maintaining their hair with minoxidil, but there are varying opinions on the effectiveness of the treatments.

    Related Research

    1 / 1 results