The Hair Loss Encyclopedia

Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

May 2023 in “ Skin research and technology ”

Areum Won, Sooho Choi, A‐Ru Kim, Jeong Ho Hong

DNA aptamer WD-aptamer Wnt/β-catenin signaling human hair follicle dermal papilla cells HFDPCs CXXC5 Dishevelled1 Dvl1 Wnt3a β-catenin cell proliferation MTT assay Wnt signaling hair follicle cells hair growth

TLDR A DNA aptamer helps promote hair growth by enhancing a key cell growth signal in hair follicle cells.

The study demonstrates that a DNA aptamer (WD-aptamer) can enhance Wnt/β-catenin signaling in human hair follicle dermal papilla cells (HFDPCs) by blocking the negative regulation mediated by CXXC5. This results in a significant increase in cell proliferation, with a 123.98% increase at a 5 μM concentration compared to the control. The findings indicate that WD-aptamer has potential as a therapeutic agent for hair regrowth by promoting dermal papilla cell activity and hair follicle development.

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Cited in this study

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research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations , May 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

37 citations , November 2017 in “Journal of Investigative Dermatology”

Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.

research The Negative Regulator CXXC5: Making WNT Look a Little Less Disheveled

8 citations , November 2017 in “Journal of Investigative Dermatology”

CXXC5 is a protein that prevents hair growth and could be a target for hair loss treatment.

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

149 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

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research Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

May 2023 in “Skin research and technology”

A DNA aptamer helps promote hair growth by enhancing a key cell growth signal in hair follicle cells.