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    Glossary Systemic Absorption

    substance enters bloodstream and spreads throughout the body

    Systemic absorption refers to the process by which a substance, such as a medication or chemical, enters the bloodstream and is distributed throughout the body. This can occur through various routes, including oral ingestion, inhalation, or through the skin. Once in the bloodstream, the substance can exert its effects on different organs and tissues, which is crucial for treatments that need to reach systemic circulation to be effective.

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    1. Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model International Journal of Pharmaceutics · 2005 · 18 citations
    2. Hypertrichosis Induced by Minoxidil: A Case of Systemic Absorption from Scalp Occlusion American Journal of Case Reports · 2025
    3. Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review JEADV Clinical Practice · 2025
    4. Topical absorption and systemic toxicity Cutaneous and Ocular Toxicology · 2011 · 19 citations
    5. Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model. Belarusian State Pedagogical University repository (Belarusian State Pedagogical University) · 2005
    6. Elevation of transaminases after MMP® session with methotrexate for alopecia areata treatment – how much do we know about the risks of systemic absorption of the technique? Anais Brasileiros de Dermatologia · 2022 · 6 citations
    7. Topical use of systemic drugs in dermatology: A comprehensive review 2011 · 19 citations
    8. Lack of endocrine systemic side effects after topical application of spironolactone in man Journal of endocrinological investigation · 1988 · 8 citations
    9. Percutaneous Absorption of Minoxidil in Man Archives of Dermatology · 1985 · 52 citations
    10. The biology and clinical application of systemic glucocorticoids Current problems in dermatology · 1992 · 5 citations
    11. Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome Pediatric dermatology · 2007 · 42 citations
    12. Liposomal systems as drug delivery vehicles for dermal and transdermal applications Archives of Dermatological Research · 2011 · 151 citations
    13. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020 · 130 citations
    14. Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods Cosmetics · 2017 · 79 citations
    15. Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 47 citations
    16. Diffuse hypertrichosis during treatment with 5% topical minoxidil British Journal of Dermatology · 1997 · 44 citations
    17. Intralesional steroids for alopecia areata International Journal of Trichology · 2010 · 36 citations
    18. The use of liposomes in the topical application of steroids Journal of Pharmacy and Pharmacology · 1984 · 33 citations
    19. Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014 · 23 citations
    20. Emerging drugs for alopecia areata: JAK inhibitors Expert opinion on emerging drugs · 2018 · 20 citations
    21. Diffuse hypertrichosis during treatment with 5% topical minoxidil British Journal of Dermatology · 1997 · 18 citations
    22. Topical minoxidil in the treatment of alopecia areata. BMJ · 1984 · 18 citations
    23. Minoxidil induced hypertrichosis in a 2 year-old child F1000Research · 2013 · 17 citations
    24. Infantile generalized hypertrichosis caused by topical minoxidil Anais Brasileiros de Dermatologia · 2016 · 10 citations
    25. Minoxidil-induced hypertrichosis: Pathophysiology, clinical implications, and therapeutic strategies JAAD reviews. · 2024 · 7 citations
    26. Lipid-based nanoformulation optimization for achieving cutaneous targeting: Niosomes as the potential candidates to fulfill this aim European journal of pharmaceutical sciences · 2023 · 6 citations
    27. Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients Dermatology practical & conceptual · 2020 · 4 citations
    28. Minoxidil topical foam: A new kid on the block International journal of trichology · 2009 · 4 citations
    29. Enhancing alopecia areata management: Nanocrystal-driven strategy for targeting hair follicles International Journal of Pharmaceutics · 2025 · 3 citations
    30. Blood pressure changes in patients after Minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial Archives of Dermatological Research · 2025 · 1 citations