Proteins from Stressed Mesenchymal Stem Cells Can Repair Hair Follicles and Promote Hair Regeneration

    Minghao Xu, Lu Diao, Xiangxiang Xu, Ao Zhu, Yu Wang, Mi Liu
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    TLDR Proteins from stressed stem cells can help regrow hair.
    This study explores a novel treatment for androgenetic alopecia (AGA) using proteins derived from stressed mesenchymal stem cells (PDSSCs) in a mouse model. The research demonstrates that PDSSCs, obtained by stimulating mesenchymal stem cells with the root extract of Atalantia monophylla, can effectively promote hair growth and activate hair follicle stem cells. This process is facilitated through the Wnt and TGF-β pathways, offering a promising alternative to traditional corticosteroid treatments, which have significant side effects. The findings suggest that stressed-MSC therapy could be a viable strategy for improving hair regeneration in AGA.
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