Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single-Arm, Multi-Center, Phase III Equivalent Clinical Study

    September 2023 in “ The Journal of Dermatology ”
    Kazutoshi Harada, Manabu Ohyama, Shiro Niiyama … Ryoji Tsuboi
    Studysummary In this study, injecting dermal sheath cup cells into affected areas of pattern hair loss improved hair thickness and patient-reported hair appearance in 62.9% of the participants, with better results in women, without serious side effects.
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    Research cited in this study 23

    1. Effective And Economical Cell Therapy For Hair Regeneration Biomedicine & Pharmacotherapy · 2022
    2. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    3. Changes in the Expression of Smooth Muscle Cell-Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022
    4. Advances in Hair Growth Faculty reviews · 2022
    5. Dermal Sheath Cells and Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    6. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    7. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    8. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    9. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    10. The Trichoscopy Derived Sinclair Scale: Enhancing Visual Assessment Through Quantitative Trichoscopy Australasian Journal of Dermatology · 2018
    11. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018
    12. Five-Year Efficacy of Finasteride in 801 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2015
    13. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    14. Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients Journal of Dermatology · 2010
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    16. Characteristic Features of Japanese Women's Hair With Aging and Hair Loss Journal of Dermatological Science · 2006
    17. Recent Findings with Computerized Methods for Scalp Hair Growth Measurements Journal of Investigative Dermatology Symposium Proceedings · 2005
    18. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    19. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    20. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    21. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    22. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992
    23. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977

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